Pharmacokinetic basis for the use of extended interval dosage regimens of gentamicin in neonates

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Pharmacokinetic basis for the use of extended interval dosage regimens of gentamicin in neonates.

OBJECTIVES To analyse the pharmacokinetic basis for the use of extended-interval dosage regimens of gentamicin in neonates using population pharmacokinetics. PATIENTS AND METHODS The population pharmacokinetics of gentamicin was studied retrospectively in a population of 113 neonates divided into two groups: one for computing the population model (n=97) and another for validation (n=36). A on...

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Gentamicin dosage intervals in neonates: longer dosage interval--less toxicity.

OBJECTIVES The aim of this study was to determine the incidence of toxic trough serum gentamicin levels in neonates in the first week of life, with different dosage intervals. METHODS This was a retrospective study of neonates born between 01.07.95 and 31.12.95, who received gentamicin. Data were collected on birth weight, gestation, gentamicin dose, the trough level of gentamicin, serum crea...

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ژورنال

عنوان ژورنال: Journal of Antimicrobial Chemotherapy

سال: 2004

ISSN: 1460-2091

DOI: 10.1093/jac/dkh261